The Clinical Trial Protocol for the Inactivated Poliomyelitis Vaccine Made From Sabin Strains(Sabin IPV)

Inclusion Criteria: * Males and females, age from 60 days to 90 days; * Adults, parent(s) or guardians are able to understand and sign informed consent for participation; * Participants or guardians are able to attend all planned clinical appointment and obey and follow all study instructions; * Infants no vaccinated with poliovaccine or other preventive biologicals in recent 7 days; * Axillary temperature ≤37℃. Exclusion Criteria: * Have medical record of participants or their family on allergy, convulsion, falling sickness, encephalopathy and psychopathy; * Low platelet or bleeding disorder do not allow vaccination into the muscle; * Have damaged or lower immunological function; * Received blood, plasma or immunoglobulin treatment since birth; * Have inborn abnormality, develop obstacles or clinical diagnostic serious chronic ( Down Syndrome, diabetes, sickle cell anemia or neural Guillain-Barre Syndrome ); * Have or be doubtful of following diseases: respiratory system diseases, acute infection or active chronic, cardiovascular diseases, liver and kidney diseases, skin diseases, HIV. Exclusion Criteria for doses 2 and 3 * Have serious anaphylaxis or high fever, convulsion during first dose; * Have any circus of Exclusion Criteria after Eligible for study; * Have serious adverse event which related to previous vaccination; Withdrawal and Discontinuance Criteria; * Received necessary or interference study drugs such as: immune-inhibition or immune-stimulating agents; * Vaccinated with any other vaccine（except DTP）; * Stop observation determined by investigator owing to occurring serious adverse event.