Efficacy and Safety of LBSA0103 Versus Hyruan Plus Injection in Patients With Knee Osteoarthritis

Inclusion Criteria: * Over 40 years of age * Kellgren \& Lawrence grade I-III * If there is more than one knee having a weight bearing pain of at least 40mm evaluated by 100mm VAS * Be willing to discontinue all nonsteroidal anti-inflammatory drugs(NSAIDs), analgesics, condroichin sulfate/glucosamine or physical therapy for the duration of the study Exclusion Criteria: * Body mass index \> 32 * Have rheumarthritis * Patients who have a weight-bearing pain of less than 40mm on both knees when measured by 100mm-VAS * Have Sudek's atrophy, Paget's disease, Spinal disc herniation * Kellgren \& Lawrence Grade IV