This trial is conducted in Europe. The aim of this trial is to determine the relative bioavailability of NNC 90-1170 (liraglutide) when inhaled compared to NNC 90-1170 when injected under the skin.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
32
Single dose of 6 mcg/kg by inhalation. Progression to open-label trial part will be based on safety data
Single dose by inhalation. Progression to open-label trial part will be based on safety data
Single dose of 12 mcg/kg by inhalation. Subjects receive treatment in random order
Unnamed facility
Tranent, United Kingdom
Ratio of the areas under the plasma NN 90-1170 curves
The maximum concentration (Cmax)
The time to maximum concentration (tmax)
Mean residence time (MRT)
Area under the curve
Terminal rate constant
Adverse events
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Single dose 6 mcg/kg injected subcutaneously. Subjects receive treatment in random order
Single dose 0.4 IU/kg by inhalation. Subjects receive treatment in random order
Single dose 0.08 IU/kg injected subcutaneously. Subjects receive treatment in random order
24 mcg/kg by inhalation. Progression to dose level will be based on safety evaluation