The investigators hypothesize that a spinal anesthetic administered prior to the induction of general anesthesia will result in reduced need for pain medication and reduced postoperative pain, as well as reduced hospital stay following a total abdominal hysterectomy.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
All patients will receive a preoperative multimodal analgesic regime: * Tylenol® 975mg per os * Naproxen® 500 mg per os Patients will receive a spinal anesthetic with: * Bupivacaine 0.5% 10 mg * Fentanyl 10ug * Epidural Morphine 150ug After the spinal, a general anesthetic will be induced using: * Midazolam 1 - 2 mg intravenously * Fentanyl 1 - 2 ug/kg intravenously * Propofol 1-3 mg/kg intravenously * Rocuronium 0.3 - 0.9mg/kg intravenously * followed by endotracheal intubation. Maintenance of anesthesia with sevoflurane, oxygen and air. * Intraoperative Morphine 0 - 0.3mg/kg or Fentanyl 0 - 7.5ug/kg to maintain MAP and heart rate within 20% of baseline. * Phenylephrine and Ephedrine can be used to support blood pressure and heart rate within 20% of baseline. * Dexamethasone 4mg and Ondansetron 4mg intravenously * Neostigmine 3mg and Glycopyrrolate 0.6mg intravenously Patients will receive a Morphine PCA to be initiated in the Post Anesthetic Care Unit (PACU).
All patients will receive a preoperative multimodal analgesic regime: * Tylenol® 975mg per os * Naproxen® 500 mg per os Group I (General anesthetic) patients will receive a general anesthetic : * Midazolam 1 - 2 mg intravenously * Fentanyl 1 - 2 ug/kg intravenously * Propofol 1-3 mg/kg intravenously * Rocuronium 0.3 - 0.9mg/kg intravenously * followed by endotracheal intubation. Maintenance of anesthesia with sevoflurane, oxygen and air. * Intraoperative Morphine 0 - 0.3mg/kg or Fentanyl 0 - 7.5ug/kg. to maintain MAP and heart rate within 20% of baseline. * Phenylephrine and Ephedrine can be used to support blood pressure and heart rate within 20% of baseline. * Dexamethasone 4mg and Ondansetron 4mg intravenously * Neostigmine 3mg and Glycopyrrolate 0.6mg intravenously Patients will receive a Morphine PCA as per protocol that will be initiated in the Post Anesthetic Care Unit (PACU).
Saskatoon City Hospital
Saskatoon, Saskatchewan, Canada
Morphine consumption
The primary outcome will be total opioid use per day, as recorded by the PCA pump and transcribed by the nursing staff in the PACU and on the post-operative ward.
Time frame: 1 day
Total Morphine consumption
The primary outcome will be total opioid use per day, as recorded by the PCA pump and transcribed by the nursing staff in the PACU and on the post-operative ward.
Time frame: Post-operative day 1
Total Morphine consumption
The primary outcome will be total opioid use per day, as recorded by the PCA pump and transcribed by the nursing staff in the PACU and on the post-operative ward.
Time frame: Post-operative day 2
Pain score on the VAS
Time frame: In the PACU: within the first 5 minutes
Pain score on the VAS
Time frame: In the PACU: after 30 minutes
Pain score on the VAS
Time frame: In the PACU: after 60 minutes.
Pain score on the VAS
Time frame: Upon arrival on the post-operative ward
Pain score on the VAS
Time frame: On the post-operative ward: after 1 hour
Pain score on the VAS
Time frame: On the post-operative ward: after 4 hours
Pain score on the VAS
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Time frame: On post-operative day 1 at 02:00
Pain score on the VAS
Time frame: On post-operative days 1 at 06:00
Pain score on the VAS
Time frame: On post-operative days 1 at 10:00
Pain score on the VAS
Time frame: On post-operative days 1 at 14:00
Pain score on the VAS
Time frame: On post-operative days 1 at 18:00
Pain score on the VAS
Time frame: On post-operative days 1 at 22:00
Pain score on the VAS
Time frame: On post-operative day 2 at 02:00
Pain score on the VAS
Time frame: On post-operative day 2 at 06:00
Pain score on the VAS
Time frame: On post-operative day 2 at 10:00
Pain score on the VAS
Time frame: On post-operative day 2 at 14:00
Pain score on the VAS
Time frame: On post-operative day 2 at 18:00
Pain score on the VAS
Time frame: On post-operative day 2 at 22:00