The aim of current study is to evaluate the efficacy and safety of oral Ibuprofen in term 20-28 days old newborn referred to Bandarabbas children' hospital in 2011.
Patent Ductus Arteriosus (PDA) accounts for about 10% of Congenital Heart Disease. Surgical treatment in PDA is associated with higher rate of complication than pharmacologic treatment. Efficacy of Ibuprofen is shown in preterm and low birth weights newborn with PDA. Studies in term neonates after the first days of birth are rare. The aim of current study is to evaluate the efficacy and safety of oral Ibuprofen in term 20-28 days old newborn referred to Bandarabbas children' hospital in 2011.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
40
10mg/kg oral ibuprofen followed by two 5mg/kg in 12 hours intervals. If there was no improvement after first cycle of treatment this treatment was repeated.
Hormozgan University of Medical Sciences
Bandar Abbas, Hormozgan, Iran
PDA closure after 1 week
PDA closure after 1 week of treatment based on echocardiography
Time frame: 1 weeks after treatment
PDA closure after two weeks
PDA closure two weeks after treatment based on echocardiography
Time frame: 2 weeks after treatment
Drug side effects
hemorrhage, abdominal distention, oliguria
Time frame: two weeks after treatment
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