Rotational Thromboelstometry (ROTEM) change_colloid_total Hip Replacement Arthroplasty

Seoul National University Bundang Hospital75 enrolled

Overview

The investigators administered different kinds of colloids before transfusion of red blood cell to patient undergoing total hip replacement arthroplasty. The investigators will compare the differences of changes in rotational thromboelastometry (ROTEM) data among them.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

NONE

Enrollment

Conditions

Avascular Necrosis of Hip Total Hip Replacement Arthroplasty

Interventions

Pentaspan, voluven, volulyteDRUG

Different colloids are administered during operation for replacement of blood loss before the transfusion of blood.

Eligibility

Sex: ALLMin age: 20 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients diagnosed as avascular necrosis of hip and undergoing total hip replacement arthroplasty Exclusion Criteria: * hematologic disease * anticoagulant medication * preoperative hemoglobin \< 10 g/dl * renal disease * pulmonary disease (pulmonary edema, effusion) * cardiovascular disease (coronary heart disease, congestive heart failure)

Locations (1)

Seoul National University Bundang Hospital

Seongnam, Gyounggi, South Korea

Outcomes

Primary Outcomes

INTEM parameters change from preoperative values at post-operation

clotting time (sec), clot firmness time (sec), alpah angle, maximum clot firmness (mm)

Time frame: 30 minutes before operation and 30 minutes after operation

EXTEM parameters change from preoperative values at post-operation

clotting time (sec), clot firmness time (sec), alpah angle, maximum clot firmness (mm)

Time frame: 30 minutes before and 30 minutes after operation.

FIBTEM parameters change from preoperative values at post-operation

maximum clot firmness (mm)

Time frame: 30 min before and 30 min after operation

Secondary Outcomes

Infused total fluid volume

crystalloid and colloid

Time frame: Participants will be followed for the duration of THRA operation in operating room, an expected average tiem of 3 hours

Hemoglobin

Time frame: 30 minutes before operation and 30 minutes after operation

postoperative blood loss

Time frame: postoperative 1 day and 2 day

Hematocrit

Time frame: 30 minutes before operation and 30 minutes after operation

Platelet

Time frame: 30 minutes before operation and 30 minutes after operation

Prothrombin Time-Internatiolnal Normalized Ratio

Data from ClinicalTrials.gov

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