Electrical Stimulation During Immobilization

Maastricht University Medical Center24 enrolled

Overview

In the present study, the effects of 5 days of lower limb immobilization with or without daily neuromuscular electrical stimulation on muscle mass and muscle fiber characteristics will be determined.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Disuse Atrophy Immobilization Neuromuscular Electrical Stimulation

Interventions

immobilizationBEHAVIORAL

Eligibility

Sex: MALEMin age: 18 YearsMax age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Male * Aged from 18-35 years * 18.5 \< BMI \< 30 kg/m2 Exclusion Criteria: * Smoking * Performing regular resistance training in the previous 6 months * Hypertension (according to WHO criteria) \[46\] and/or cardiovascular disease * Any back/leg/knee/shoulder complaints which may interfere with the use of crutches * Use of any prescribed medication * Type 2 diabetes mellitus * Any family history of thrombosis * All co-morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthritis, spasticity/rigidity, all neurological disorders and paralysis). * Myocardial infarction within the last 3 years * Use of anti-coagulants

Locations (1)

Maastricht University Medical Centre

Maastricht, Netherlands

Outcomes

Primary Outcomes

muscle mass, muscle fiber size

Time frame: three days before immobilization, and directly after immobilization (day of cast removal; day 6)

Secondary Outcomes

muscle strength measured by quadriceps 1-Repetition Maximum by Leg Extension

Time frame: three days before immobilization, and directly after immobilization (day of cast removal; day 6)

Data from ClinicalTrials.gov

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