An open-label, single-dose, two-treatment, randomized, cross-over study to investigate the effects of the SLCO2B1 c.1457C\>T polymorphism and apple juice on the pharmacokinetics and pharmacodynamics of acebutolol in healthy Korean and Japanese volunteers
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
16
Acebutolol
Placebo capsule(Capsules filled up with lactose)
General Clinical Research Center, Oita University Hospital
Ōita, Japan
Seoul National University Hospital
Seoul, South Korea
AUC of acebutolol according to the SLCO2B1 genotypes
The area under the plasma concentration versus time curve, from time 0 to the last measurable concentration, as calculated by the linear/log trapezoidal method will be summarized by treatment and genotype group using descriptive statistics.
Time frame: 0-24 hr after drug administration
Blood pressure of the subjects who administered acebutolol according to the SLCO2B1 genotypes
Blood pressure (systolic, diastolic) measurement will be presented as descriptive statistics for the difference from baseline where appropriate.
Time frame: 0-24 hr after drug admnistration
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