Exercise and Systemic Lupus Erythematosus

University of Sao Paulo90 enrolled

Overview

The investigators hypothesize that a three-month aerobic exercise training program will positively affect the lipid profile, insulin sensitivity , cytokine profile, the cardiovascular parameters and muscle strength in SLE patients.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Systemic Lupus Erythematosus

Interventions

Exercise trainingBEHAVIORAL

Aerobic exercise training, two times a week

Eligibility

Sex: FEMALEMin age: 7 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age between 7 and 40 years * SLEDAI ≤ 4 Exclusion Criteria: * Cardiovascular dysfunction * Rhythm and conduction disorders * Musculoskeletal disturbances * Kidney and pulmonary involvements * Peripheral neuropathy * Use of tobacco * Treatment with lipid-lowering or hypoglycemic drugs * Fibromyalgia * Use of chronotropic or antihypertensive drugs * Physically active subjects

Locations (1)

University of Sao Paulo

São Paulo, São Paulo, Brazil

Outcomes

Primary Outcomes

Lipid profile - Plasma levels of total cholesterol (mg/dl), VLDL-chol (mg/dl) HDL-chol (mg/dl), LDL-chol (mg/dl), triglycerides (mg/dl), Apolipoprotein AI and AII (mg/dl) and Apolipoprotein B (mg/dl)

Time frame: 3 months

Insulin sensitivity as measured by the Hyperinsulinemic-Euglycemic Clamp

Time frame: 3 months

Cytokine response - Plasma levels of TNF-α (pg/ml), IL-6 (pg/ml), IFN-type I (pg/ml), IL-10 (pg/ml)and IL-1ra (pg/ml)

Time frame: 3 months

Secondary Outcomes

Cardiovascular parameters

Aerobic capacity, chronotropic function

Time frame: 3 months

Muscle Strength

Upper and Lower-body muscle strength will be assessed by a 1-RM (repetition maximum) protocol

Time frame: 3 months

Data from ClinicalTrials.gov

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