This trial is conducted in Japan. The aim of this trial is to assess the safety and tolerability of 20 µg/kg and 25 µg/kg liraglutide in healthy Japanese male subjects.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
24
One daily subcutaneous dose for 5 weeks. Dose is weekly incremented with 5 mcg/kg
One daily subcutaneous dose for 5 weeks. 5 mcg/kg the first week, then 10 mcg the second week followed by 15 mcg the third week, and finally 20 mcg for 2 weeks
One daily subcutaneous dose for 5 weeks. 5 mcg/kg the first week, then 10 mcg the second week followed by 15 mcg for 3 weeks
Novo Nordisk Investigational Site
Tokyo, Japan
Adverse events
Body weight
Antibody against liraglutide
Area under the plasma liraglutide concentration curve
Cmax, maximum concentration
tmax, time to reach Cmax
Terminal elimination rate constant
t½, terminal elimination half-life
24-hour profiles of plasma glucose
24-hour profiles of serum insulin
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Liraglutide placebo administered to subjects randomised at each dose level in the ratio of 3:1