Hemocontrol's Effectiveness on the Reduction of Cardiovascular Long-term EventS

Inclusion Criteria: 1. Age more than 65 years old 2. Arterial Hypertension: predialysis SBP \>140 mmHg and/or DBP \>90 mmHg in at least 50% over the previous month dialysis sessions or receiving at least one antihypertensive pharmacological drug including diuretics, disregarded blood pressure value 3. On a three times per week hemodialysis schedule 4. Time on hemodialysis less than 6 months 5. Able to measure their blood pressure at home (by themselves or with the aid of the care giver) 6. Signed informed consent Exclusion Criteria: 1. Active neoplastic disease 2. Mental illness 3. Pregnancy 4. Single needle treatment 5. Inability, as judged by the investigator, to follow or understand the protocol instructions 6. Blood flow rate less than 200 mL/min 7. Patients who at the time of recruitment need clinical indication for special renal replacement therapies and/or on treatment with one of the following modalities: HDF or similar diffusive-convective therapies, treatment time \>5h, blood temperature control, isolated UF profiling of Na/UFR 8. Patients with a life expectancy shorter than 6 months 9. Patients in a list for transplant within the next 6 months 10. Predialysis Hemoglobin level greater than 13.5 g/dl 11. History of major cardiovascular events during run in period