Citicoline and Omega-3 Fatty Acid Effects in Veterans With Traumatic Brain Injury (TBI)

Inclusion Criteria: * Veteran status * Age 18 to 55 * History of TBI * DSM-IV-TR diagnosis of abuse or dependence disorder for either alcohol or drugs of abuse * Multiple concussive head injuries that meet the following criteria for TBI: 1) normal structural imaging, 2) loss of consciousness (LOC) between 0-30 minutes, 3) alteration of consciousness or mental status for a moment up to 2 hours or 4) post-traumatic amnesia of 0-1 day * Stable on current psychotropic medication regimen for ≥ 3 months Exclusion Criteria: * Non Veteran * Significant medical or neurological illness with the exception of TBI, which might affect cognitive function * Significant medical illness which has the potential to be exacerbated by ingestion of citicoline/omega-3 fatty acids, including diabetes, congestive heart disorder, hyperlipidemia and severe coronary artery disease * Age other than 18 to 55 years old * History of ECT treatment * Estimated IQ \< 70 * Past or present history of bipolar disorder, schizophrenia, delusional disorder or any other psychotic disorder * Currently taking a prescribed blood thinner (i.e., Coumadin) * Claustrophobia * Metal implanted within the body * Pregnancy or lactation * Left-handedness * Poor vision, as subjects must have normal or corrected-to-normal vision for viewing of cognitive challenge paradigms during fMRI protocols * Non-native English speakers (for neurocognitive tasks)