Photosensitivity is well documented among lupus patients and is one of the diagnostic criteria for systemic lupus erythematosus (SLE). Photosensitivity is highly prevalent in lupus and has a wide range of clinical presentations. However, photosensitivity is a poorly defined in lupus and its pathogenesis is not well understood. The purpose of this study is to characterize the early clinical and histopathological changes in lupus skin that occur as a response to ultraviolet light.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
19
Single MED dose on Day 2
University of Pennsylvania
Philadelphia, Pennsylvania, United States
The change from baseline of the neutrophil and inflammasome response to ultraviolet radiation at 24 hours.
Time frame: 24 hours and 48 hours
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