Phase II Study of Alternating Sunitinib and Temsirolimus

Inclusion Criteria * Histologically confirmed metastatic renal cell cancer with evaluable disease. * Patients must be at least 2 weeks from their last immunotherapy, surgery or chemotherapy (6 weeks for nitrosureas) and recovered from all ill effects. * Karnofsky Performance Status ≥60% * Life expectancy ≥ twelve weeks * Adequate end organ function: Cardiac Left ventricular ejection fraction (LVEF) ≥lower limit of institutional normal (LLN) as assessed by echocardiography (ECHO) . The same modality used at baseline must be applied for subsequent evaluations. * Women should not be lactating and, if of childbearing age, have a negative pregnancy test within two weeks of entry to the study and practicing acceptable forms of birth control * Appropriate Contraception in both sexes * The patient must be competent and signed informed consent. EXCLUSION CRITERIA * Concomitant second malignancy except for non-melanoma skin cancer, and non-invasive cancer such as cervical CIS, superficial bladder cancer without local recurrence, breast CIS. * In patients with a prior history of invasive malignancy, less than five years in complete remission. * Have evidence of significant co-morbid illness such as uncontrolled diabetes, hypertension or active infection that would preclude treatment on this regimen. * Prior treatment with either sunitinib or temsirolimus * Clinically significant gastrointestinal abnormalities * Presence of uncontrolled infection. * Prolongation of corrected QT interval (QTc) \> 480 milliseconds - History of any one or more of the following cardiovascular conditions within the past 12 months: 1. Cardiac angioplasty or stenting 2. Myocardial infarction 3. Unstable angina 4. Coronary artery by-pass graft surgery 5. Symptomatic peripheral vascular disease 6. Class III or IV congestive heart failure, as defined by the New York Heart Association (NYHA) * History of cerebrovascular accident (CVA) including transient ischemic attack (TIA) within the past 12 months. * History of pulmonary embolism or untreated deep venous thrombosis (DVT)within the past 6 months. Note: Subjects with recent DVT who have been treated with therapeutic anticoagulating agents for at least 6 weeks are eligible. * Poorly controlled hypertension \[defined as systolic blood pressure (SBP) of ≥150 or diastolic blood pressure (DBP) of ≥ 90. Note: Initiation or adjustment of antihypertensive medication(s) is permitted prior to study entry. * Prior major surgery or trauma within 28 days prior to first dose of study drug and/or presence of any non-healing wound, fracture, or ulcer. * Evidence of active bleeding or bleeding diathesis * Hemoptysis within 6 weeks of first dose of study drug. * Known endobronchial lesions and/or lesions infiltrating major pulmonary vessels * Any serious and/or unstable pre-existing medical, psychiatric, or other conditions that could interfere with subject's safety, obtaining informed consent or compliance to the study. * Is now undergoing and/or has undergone in the 14 days immediately prior to first dose of study drug any minor surgeries (i.e. skin biopsy, tooth extraction, etc.) and recovered from all ill effects. * Any ongoing toxicity from prior anti-cancer therapy that is \>Grade 1 and/or that is progressing in severity. * Known immediate or delayed hypersensitivity reaction or idiosyncrasy to drugs chemically related to sunitinib or temsirolimus. * Untreated brain metastasis. (Brain metastases that are stable based on radiographic evidence 4 weeks after radiation and/or surgery are permitted).