Arestin - Use in Subjects With Peri-Implantitis (With Subgingival Microbiological Evaluation)

Inclusion Criteria: * A minimum of one osseointegrated implant with a diagnosis of peri-implantitis * Absence of any significant oral soft tissue pathology * At least one peri-implant site with an average of 2 probing depth readings between 5mm and 7mm (inclusive) when using a light force and with bleeding on probing within 30 seconds of the probing * Confirmed evidence of pathologic bone loss * At least 1mm of keratinized gingiva present around the implant Exclusion Criteria: * Pregnancy * Allergy to tetracycline-class drug(s) * Systemic medical condition(s) requiring antibiotic prophylaxis prior to invasive dental procedures * Presence of active systemic infectious disease such as hepatitis, HIV, history of tuberculosis * Diagnosis of clinically significant or unstable organic disease, or compromised healing potential * Signs of untreated advanced periodontal disease and/or poor oral hygiene * Subjects having a probing depth greater than 8mm at time of enrollment * Subjects presenting with mobility of any dental implant * Subjects having a qualifying implant under occlusal trauma or overloaded (as determined by the investigator)