Evaluating Cardiovascular Phenotypes Using Induced Pluripotent Stem Cells

N/AEnrolling By InvitationNCT01517425

Scripps Translational Science Institute200 enrolled

Overview

This research is being done to understand how changes in DNA may put people at risk for developing coronary artery disease. Stem cells will be made using cells from blood and/or skin biopsy samples. We are trying to understand which specific changes in DNA negatively impact a person's health.

Study Type

OBSERVATIONAL

Enrollment

200

Conditions

Coronary Artery Disease

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: Cases: 1. Previously enrolled in the CAD module of the Genebank at Scripps Clinic Registry 2. Eligible to have their blood drawn 3. Be reliable, cooperative and willing to comply with all protocol-specified procedures 4. Able to understand and grant informed consent Controls: 1. Previously enrolled in the Healthy Elderly Active Longevity (HEAL) Cohort 2. Eligible to have their blood drawn 3. Be reliable, cooperative and willing to comply with all protocol-specified procedures 4. Able to understand and grant informed consent Exclusion Criteria: 1. Unwilling or unable to grant informed consent. 2. Have a significant medical condition that in the Investigator's opinion may interfere with subject's study participation.

Locations (1)

Scripps Translational Science Institute

La Jolla, California, United States

Outcomes

Primary Outcomes

iPSC development

Develop methods of iPSC generation from patients with genomic risk.

Time frame: five years

Data from ClinicalTrials.gov

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