Retinal function is highly dependent on the glucose supply. Thus, functional adaptations occur in response to both acute and long-term changes in glycaemia. The purpose of this study is to examine functional and metabolic aspects of retinal adaptation to long-lasting changes in glycaemic control in patients with diabetes. The adaptational phenomena will be characterized by electroretinography, dark adaptation, measures of retinal perfusion and oximetry as well as diabetic retinopathy grading and (OCT).
Study Type
OBSERVATIONAL
Enrollment
100
Insulin pump therapy
Multiple daily insulin injections
Pre-operative weight loss and bariatric surgery.
Medical glucose-lowering therapy and non-surgical weight-lowering interventions.
Department of Ophthalmology, Glostrup Hospital
Glostrup Municipality, Denmark
RECRUITINGChanges in dark adaptation kinetics and threshold values, amplitudes/implicit times, retinal vessel diameters, perfusion velocity and oximetry.
Time frame: Baseline, 1 week, 1 month, 4 months, 7 months, 12 months, 18 months, 24 months, 42 months
Changes in visual acuity, diabetic retinopathy grading and OCT
Time frame: Baseline, 1 week, 1 month, 4 months, 7 months, 12 months, 18 months, 24 months, 42 months
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