The study will investigate the effectiveness of Cognitive Therapy and Acceptance and Commitment Therapy in a randomized controlled trial among patients with Major Depressive Disorder in routine clinical practice. Furthermore, the study will investigate whether each specific treatment approach is mediated by its proposed theoretical mechanism.
The current study aims at investigating the effectiveness of Cognitive Therapy and Acceptance and Commitment Therapy in a randomized controlled trial among patients with MDD in routine clinical practice. Further, the study will investigate whether each specific treatment approach is mediated by its proposed theoretical mechanism. Patients have to meet diagnostic criteria for nonpsychotic MDD as determined by the Structured Interview for DSM-IV. Each client will receive either Cognitive Therapy or Acceptance and Commitment Therapy that will last between 16 to 20 sessions. Based on previous results, it is expected that both treatment forms will prove beneficial for the patients.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
82
This interventions will target: (a) behavioral dysfunction, (b) situation-specific negative thinking and cognitive distortions, and (c) underlying dysfunctional beliefs or cognitions assumed to be related to the patient's current depression and risk of future depression. A maximum of 20 45-55 minute sessions will be provided, with sessions generally held weekly for the first 8 sessions and once every two weeks for the next 8 sessions.
This interventions will use (a) acceptance, (b) commitment, (c) mindfulness, and (d) behavior change processes to produce reduction of depressive symptoms. A maximum of 20 45-55 minute sessions will be provided, with sessions generally held weekly for the first 8 sessions and once every two weeks for the next 8 sessions.
PsyQ
Zaandam, Netherlands
QUICK INVENTORY OF DEPRESSIVE SYMPTOMATOLOGY (QIDS-SR)
Change from pre-treatment to post-treatment, 6 months follow-up and 12 months follow-up
Time frame: pre-treatment, post-treatment, 6 and 12 months follow-up
Hamilton Rating Scale for Depression
Change from pre-treatment to post-treatment.
Time frame: pre-treatment, post-treatment
Decentering subscale of the Experiences Questionnaire
Change between sessions and to follow-up.
Time frame: Pre-treatment, in-treatment, and 6 and 12 months follow-up.
Acceptance and Action Questionnaire
Change between sessions and to follow-up.
Time frame: Pre-treatment, in-treatment, and 6 and 12 months follow-up.
Dysfunctional Attitude Scale-revised
Change between sessions to follow-up.
Time frame: Pre-treatment, in-treatment, and 6 and 12 months follow-up
Working Alliance Inventory
Time frame: 3. session
Eurohis Quality of Life Scale
Change pre-treatment to post-treatment and to follow-up.
Time frame: Pre-, post-treatment, 6 and 12 months follow-up
Relationship Scales
Change pre-treatment to post-treatment and to follow-up.
Time frame: Pre-, post-treatment, 12 months follow-up
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Implicit Attitude Test
Change pre-treatment to post-treatment
Time frame: Pre- and posttreatment
Structured Clinical Interview for DSM-IV (Major Depression Module)
Change in diagnosis of Major Depression Disorder from pre-treatment to post-treatment.
Time frame: Pre-treatment and post-treatment.