Open Label Trial of NanoDOX Hydrogel in Orthopedic Trauma Wounds With and Without Vacuum Assisted Closure Therapy

Inclusion Criteria: * Be 18 years of age or older * Women of childbearing potential must have a negative urine pregnancy test at screening and at baseline * Agree to use a double-barrier method of contraception during their participation in this study * condoms (with spermicide) and hormonal contraceptives OR * condoms (with spermicide) and intrauterine device OR * intrauterine device and hormonal contraceptives OR * Abstains from sexual intercourse during their participation in this study * Is with a same-sex partner and does not participate in bisexual activities where there is a risk of becoming pregnant * Have a full-thickness trauma wound that is between 1.2cm2 and 24cm2 at initial screening * Be able to apply study drug to their wound, or have a reliable and capable caregiver do it * Subjects will have adequate blood flow to the wound as defined by transcutaneous oxygen tension (TcpO2) of \>30mmHg recorded over intact epidermis at the wound margin. Exclusion Criteria: * Less than 18 years of age * Pregnant or lactating woman or a female of childbearing potential who is not practicing acceptable form of birth control. * Allergic to tetracycline, minocycline, demeclocycline, or any other known tetracycline derivative * Tested positive for a doxycycline-resistant infection * Have undergone treatment with systemic corticosteroid or immunosuppressive therapy in the past 2 months * Currently undergoing dialysis for renal failure * Have participated in another clinical research trial within the last 30 days * Subject has wounds resulting from any cause other than trauma (diabetes, electrical burn, arterial insufficiency, chemical or radiation insult) * Active or previous (within 60 days prior to the study screening visit) chemotherapy * Active or previous (within 60 days prior to the study screening visit) radiation to the affected wound area to be treated by investigational drug or placebo * Physical or mental disability or geographical concerns (residence not within reasonable travel distance) that would hamper compliance with required study visits * The Investigator believes that the subject will be unwilling or unable to comply with study protocol requirements, including the shock wave treatment procedure, standard-of-care self-care requirements, and all study-related follow up visit requirements. * History of sickle cell anemia * History of infection with Human Immunodeficiency Virus * History of other immunodeficiency disorders * Severe anemia - Hgb \< 7 g/dl (males) or \< 6.5 (females)