Rapid Renal Sympathetic Denervation for Resistant Hypertension

Inclusion Criteria: 1. Systolic blood pressure ≥ 160 mmHg despite treatment with a regimen of 3 or more anti-hypertensive medications that includes a diuretic and that has been stable for 2 weeks prior to screening. 2. Age 18-85 years. 3. Able to provide informed consent and comply with follow-up visits. Exclusion Criteria: 1. Diameter of left or right renal artery less than 4 mm or greater than 7mm. 2. Length of target segment of left or right renal artery less than 20mm. 3. Other renal arterial abnormalities including severe renal artery stenosis, previous renal stenting or angioplasty. 4. End-stage renal disease requiring dialysis or renal transplant. 5. estimated Glomerular Filtration Rate \< 45 mL/min per 1.73 m2. 6. Type 1 diabetes mellitus. 7. Myocardial infarction, unstable angina, or cerebrovascular events within 6 months prior to screening. 8. Severe valvular heart disease for which reduction of blood pressure would be considered hazardous. 9. Bleeding disorder or refusing blood transfusions. 10. Pregnancy or breast feeding. 11. Peripheral vascular disease precluding catheter insertion. 12. Any serious medical condition, which in the opinion of the investigator, may adversely affect the safety or effectiveness of the participant or the study. 13. Current enrollment in another investigational drug or device Study.