Recurrence of Hepatocellular Carcinoma

Inclusion Criteria: 1. Proved diagnosis of HCC according to AASLD practice guidelines (Bruix and Sherman, 2005). 2. Patients underwent RFA for HCC with BCLC (The Barcelona-Clinic- Liver-Cancer staging system) stage A (Bruix and Sherman, 2005) with no eligibility or ability to do transplantation or resection. 3. Patients should be followed-up for more than 12 months to exclude early recurrence i.e. recurrence within 1 year. 4. Patients with INR \< 1.5 or prothrombin concentration \> 50%. 5. Platelet count \> 50000 cell/mm3. Exclusion Criteria: 1. Presence of extra-hepatic metastasis or gross vascular invasion. 2. Child class C patients. 3. Follow up period of less than 12 months.