The purpose of this study is to determine if an oral probiotic tablet taken once a day for twelve weeks can decrease the numbers of bacteria that are associated with tooth decay and gum disease in a dentally healthy, young adult population.
There are over 500 types of bacteria in the mouth. Most of these bacteria do not cause disease. However, some mouth bacteria can cause tooth decay and gum disease. The purpose of a probiotic tablet for the mouth is to put known healthy bacteria in the mouth. This study will compare the effect of the probiotic tablet on the levels of harmful or disease causing bacteria in the mouth to a placebo tablet that does not contain any probiotic bacteria.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Masking
TRIPLE
Enrollment
48
Probiotic mint tablet taken once daily for 12 weeks containing ProBiora3, a combination of three known healthy bacteria
Mint tablet taken once daily for 12 weeks without the ProBiora3 combination of three known healthy bacteria
University of Washington, Scool of Dentistry, Regional Clinical Dental Research Center
Seattle, Washington, United States
RECRUITINGEnumeration of S. mutans in saliva and seven periodontal pathogens in subgingival plaque
Quantitative RT-PCR analyses for S. mutans in saliva, and A. actinomycetemcomitans, P. intermedia, T. forsythia, F. nucleatum, C. rectus, and E. corrodens in subgingival dental plaque.
Time frame: 12 weeks
Breath odor
Halimeter used to evaluate breath odor
Time frame: 12 weeks
Teeth whiteness
Teeth whiteness measured with VITA Toothguide 3D-MASTER
Time frame: 12 weeks
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