The investigators propose to examine the relationship between DO2 and VO2 in critically ill patients requiring an Extracorporeal Membrane Oxygenation (ECMO) machine. This machine can provide complete support of heart and lung function. In so doing, the investigators will be able to avoid physiologic coupling by increasing DO2 mechanically, by increasing blood flow through the ECMO circuit. Null Hypothesis: Increased oxygen delivery, by means of an increased rate of extracorporeal blood flow, is not associated with an increase in oxygen consumption. Alternate Hypothesis: Increased oxygen delivery, by means of an increased rate of extracorporeal blood flow, is associated with an increase in oxygen consumption.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
11
Extracorporeal Membrane Oxygenation (ECMO) machine can provide complete support of heart and lung function. Extracorporeal blood flow will be given at baseline rate, increased by 25% and decreased by 25%
The Hospital for Sick Children
Toronto, Ontario, Canada
Oxygen consumption (VO2)
VO2 will be measured using a mass spectrometer as this is the gold standard.
Time frame: Baseline
Oxygen consumption (VO2)
VO2 will be measured using a mass spectrometer as this is the gold standard.
Time frame: 30min
Oxygen consumption (VO2)
VO2 will be measured using a mass spectrometer as this is the gold standard.
Time frame: 60min
Oxygen consumption (VO2)
VO2 will be measured using a mass spectrometer as this is the gold standard.
Time frame: 90min
Arterial serum lactate level
Time frame: Baseline, 30min, 60min, 90min
Oxygen extraction ratio.
Time frame: Baseline, 30min, 60min, 90min
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