The goal of this study is to show the superiority in survival at hospital admittance and in neurological outcome on hospital discharge of continuous mechanical chest compression using LUCAS device versus manual chest compressions in patients who suffered an out-of-hospital cardiac arrest.
The primary goals of the trial are: * To show a survival increase at hospital admittance after out-of-hospital cardiac arrest of patients treated by continuous chest compressions LUCAS device compared with patients treated by manual chest compressions. * To evaluate neurological outcome on hospital discharge, in two centres (Vall d'Hebron Hospital and Josep Trueta Hospital).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
400
LUCAS device will be placed on patients suffering a cardiac arrest and continuous chest compressions will be performed, even while defibrillation is being applied
Manual CPR according to 2010 ERC guidelines will be performed
Hospital Vall d'Hebron
Barcelona, Barcelona, Spain
RECRUITINGSistema d'Emergències Mèdiques
L'Hospitalet de Llobregat, Barcelona, Spain
RECRUITINGSurvival at hospital admittance
The primary goal is to evaluate survival at hospital admittance of patients, after out-of hospital cardiac arrest treated by LUCAS device chest compressions, compared with those patients treated by manual chest compressions
Time frame: 2 hours
Survival on discharge from hospital (or 30 days if not applicable) in acceptable neurological state (CPC scale 1 or 2)
Evaluate the neurological outcome on hospital discharge, in two centres (Vall d'Hebron Hospital in Barcelona and Josep Trueta Hospital in Girona) 1 or 2 in Cerebral Performance Category
Time frame: 30 days
Restoration of spontaneous circulation
To compare the return of spontaneous circulation (ROSC) between both groups
Time frame: 2 hours
EndTidal CO2 values
To compare EndTidal CO2 values of patients during cardiopulmonary resuscitation (CPR)between boths study arms
Time frame: Every four minutes during resuscitation maneuvers
SOFA scale values
To compare the first three days, on hospital discharge SOFA scale value and the worse value obtained (date and hour) in patients who survived out-of-hospital SCA and weere brought to either Vall d'Hebron Hospital or Josep Trueta Hospital.
Time frame: During the first three days and on hospital discharge
Days before discharge from Intensive Care Unit (ICU) / Coronary Care Unit (CCU)
To compare days before discharge from Intensive Care Unit (ICU) / Coronary Care Unit (CCU) in patients who survived out-of-hospital SCA and were brought to either Vall d'Hebron Hospital or Josep Trueta Hospital
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Time frame: 30 days
Metabolic (pH, lactate) and inflamatory (leukocytes, C reactive protein) parameters
To establish the differences in metabolic (pH, lactate) and inflamatory (leukocytes, C reactive protein) parameters in patients who survived out-of-hospital SCA and were brought to either Vall d'Hebron Hospital or Josep Trueta Hospital
Time frame: During the first 24h, at >48h and at 5-7days
Epidemiology of Out-of-Hospital Cardiac Arrest
To describe the epidemiology of out-of-hospital SCA in the cities of Barcelona, Girona and Lleida
Time frame: 3 months
To obtain a blood sample for genetic and biological studies
Blood samples from SCA survivors will be kept to perform biological studies.
Time frame: 7 days
Left ventricular function
To compare left ventricular function in patients who survived at out-of-hospital sudden cardiac arrest and were brought to either Vall d'Hebron Hospital or Josep Trueta Hospital
Time frame: During the first 24h and during the 24h previous on hospital discharge or at two months