The Efficacy of Neuromuscular Electrical Stimulation to Attenuate Muscle Loss

Hasselt University15 enrolled

Overview

Subjects who are hospitalized in the ICU will be included after 24 hours of intubation during their ICU stay. Twice-daily Neuromuscular Electrical Stimulation (NMES) will be performed on one leg for 2x40 min per day to assess muscle fiber size. The investigators hypothesize an attenuated loss in muscle fiber size.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Muscle Disuse Neuromuscular Electrical Stimulation (NMES)Critical Illness

Interventions

Neuromuscular Electrical Stimulation of m. quadriceps femorisPROCEDURE

Neuromuscular Electrical Stimulation of m. quadriceps femoris by using a commercially available muscle stimulator

Sham-treatment: no NMESPROCEDURE

Sham comparator

Eligibility

Sex: MALEMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Male * Age between 18 and 80 years * Expected sedated time of \>24h Exclusion Criteria: * Spinal Cord Injury * Arterial operaties on the legs * Local wounds that prohibit NMES * Chronic use of corticosteroids * Intake of certain antithrombotic drugs * Presence of implantable cardioverter defibrillator and/or pacemaker

Locations (1)

Jessa Hospital

Hasselt, Belgium

Outcomes

Primary Outcomes

Change in muscle fiber cross sectional area (CSA)

Muscle fiber cross sectional area (in um2) for type I and II fibers will be analyzed by using immunohistochemistry; the change of muscle fiber CSA over time will be measured

Time frame: 3 hours before and 12 hours after 10 days of twice-daily NMES

Secondary Outcomes

Change in upper leg circumference

Upper leg circumgerence will be measured; the change of upper leg circumference over time will be measured

Time frame: 3 hours before and 12 hours after 10 days of twice-daily NMES

Data from ClinicalTrials.gov

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