This study will examine the effects of a dietary fiber on insulin sensitivity in overweight and obese women. The fiber will be added to snack foods and women will consume the foods for four weeks. In one four-week period, 15 g of fiber will be added, and 30 g will added in another period. In a third period, no fiber will be added to the snack foods. Insulin senstivity will be measured at the end of each treatment period.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
40
Dietary fiber will be added to snack foods
Clinical Research Unit
Birmingham, Alabama, United States
Insulin sensitivity
A frequently sampled intravenous blood glucose tolerance test will be performed.
Time frame: 5-hr test, performed 3 times within a 20-week period
Mitocondrial function
A muscle biospy will be taken to assess mitochondrial function
Time frame: 3 times, with a 20-week period
Meal tolerance test
A high-fat meal will be given and blood will be drawn over a three-hr period
Time frame: 3 times, within a 20-week period
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