Study of Catheter Based Renal Denervation Therapy in Hypertension

Inclusion Criteria: * They have a mandatory \> 3 antihypertensive medication therapy, including a thiazide or a loop diuretic (according to the patient's renal function, unless documented side-effects) and at least one attempt to treat with spironolactone, given at usual recommended dose since at least 8 weeks, before inclusion, * A mandatory check list of secondary cause of hypertension has been excluded * They succeed the pill count test. * They have a mandatory ambulatory blood pressure monitoring before inclusion with at least 70% of valid readings during daytime (08:00 am 08:00 pm, using a sampling frequency of 20 minutes, only devices validated according to http://www.dableducational.org are permitted), where daytime ambulatory blood pressure of systolic and/or diastolic blood pressure exceeds 135 mmHg and/or 85 mmHg, respectively. Daytime ambulatory blood pressure of systolic and/or diastolic blood pressure below 135 mmHg and/or 85 mmHg, respectively, is acceptable for inclusion in the study if the patient takes four or more antihypertensive medication (3). Exclusion Criteria: * Patients with an eGFR \<30ml/min/m² are excluded, * patients with known renal atherosclerotic lesions, * previous procedures in the renal arteries, * known unsuitable anatomy for the procedure, * previous nephrectomy, * contrast agent allergy, * hyperthyroidia.