Pharmacokinetics/Pharmacodynamics of NOX-H94 in the Human Endotoxemia Model

Main Inclusion Criteria: * BMI between 18 and 30 kg/m², with a lower limit of body weight of 50 kg * Healthy as determined by medical history, physical examination, vital signs, 12 lead electrocardiogram, and clinical laboratory parameters * Serum iron and red blood parameters Hb, MCV, ferritin, serum iron, and total iron binding capacity within reference range Main Exclusion Criteria: * Use of any medication, recreational drugs or anti-oxidant vitamin supplements within 7 days * Use of caffeine, nicotine, or alcohol within 1 day * Previous participation in a trial where LPS was administered * Surgery or trauma with significant blood loss or blood donation within 3 months * History, signs or symptoms of cardiovascular disease (vaso-vagal collapse or of orthostatic hypotension, Resting pulse rate ≤45 or ≥100/min, Hypertension, Hypotension, ECG conduction abnormalities) * Renal impairment: plasma creatinine \>120 µmol/L * Liver function tests (alkaline phosphatase, AST, ALT and γ-GT) outside of the reference range or total bilirubin \>20 µmol/L * Hemoglobin or iron parameters (iron, transferring saturation, ferritin) outside of the reference ranges * History of asthma * Immuno-deficiency * Positive test of HIV type 1/2 antibodies, HBs antigen, HBc antibodies and HCV antibodies unless antibody titer is induced by vaccination * CRP \> reference range or clinically significant acute illness, including infections, within 2 weeks * Treatment with investigational drugs or participation in any other clinical trial within 30 days prior to study drug administration * Known or suspected of not being able to comply with the trial protocol * Inability to personally provide written informed consent and/or take part in the study