Influence of Breakfast Consumption on Chlorogenic Acid Metabolism in Humans

Société des Produits Nestlé (SPN)14 enrolled

Overview

Data and knowledge gathered on bioavailability of coffee phenolics is becoming more and more important, hence underlying the importance of better understanding the fate of these potential health promoting antioxidants. However, some analytical barriers as well as some key aspects of metabolism still remain to be fully elucidated to get the full picture of coffee metabolism and bioavailability. One aspect addressed in the present study is the impact of food matrix in modulating absorption, plasma appearance and urinary excretion of coffee bioactives.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Healthy

Interventions

Soluble CoffeeOTHER

Amounts of chlorogenic acids will be normalized to body weight (3.1 mg CA / kg BW). Coffee will be reconstituted in 200 mL hot water and consumed 3 times in a row (min 1-week interval), alone or with a breakfast: * 200 mL coffee or * 200 mL coffee + 2 bread rolls + honey * 200 mL coffee + 1 bread roll + peanut butter

Eligibility

Sex: ALLMin age: 20 YearsMax age: 44 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy men and women * Aged 20-44 years * Caucasian origin * Body mass index (BMI) 19-25 kg/m2 * Used to drinking coffee (similar to study coffee) on a daily basis * Being able to tolerate a 48-hour coffee abstinence * Normal oral glucose tolerance test * Having signed the informed consent form Exclusion Criteria: * Taking medication or dietary supplements * Smoking * Performing a competitive sport * Having metabolic disorders * Long gut transit time (\>24 h) * Blood donor * Irregularity in menstrual cycle (for women) * Pregnancy (for women) * Subject who cannot be expected to comply with the study procedures. * Currently participating or having participated in another clinical trial during the last 4 weeks prior to the beginning of this study.

Locations (1)

University of Kaiserslautern

Kaiserslautern, Germany

Outcomes

Primary Outcomes

Sum of plasma areas under the curve of coffee phenolics

Time frame: Measurements over 24h after coffee ingestion

Secondary Outcomes

Plasma AUC, Cmax and Tmax of individually measured coffee chlorogenic and phenolic acids

Time frame: Measurements done over 24h after coffee ingestion

Urinary excretion of coffee chlorogenic and phenolic acids expressed as % ingested dose

Time frame: Measurements done over 24h after coffee ingestion

Data from ClinicalTrials.gov

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