The study is a prospective cohort study following breast cancer patients from before surgery to one year after. The aims of the study are to determine risk factors that predispose to the development of persistent pain.
The aim of the study is 1) to determine pre-, intra and post surgical risk factors for persistent pain after breast cancer treatment 2) to examine the prevalence of persistent pain 6 and 12 months after surgery 3) provide a quantitative sensory testing (QST) profile of the patient population, measured pre surgery, 1 week and 12 months after surgery.
Study Type
OBSERVATIONAL
Enrollment
545
Rigshospitalet, Copenhagen University Hospital
Copenhagen, Denmark
Risk factors predisposing for persistent pain after breast cancer treatment
Pre-, intra- and postoperative risk factors predisposing for persistent pain
Time frame: 12 months postoperative
Prevalence of persistent pain after breast cancer treatment
Time frame: 12 months postoperative
Prevalence of sensory disturbances after breast cancer treatment
Time frame: 12 months
Correlation of persistent pain after breast cancer treatment and damage of the intercostobrachial nerve
Time frame: 12 months
Quantitative sensory testing: profile and correlation to persistent pain, sensory disturbances, signs of neuropathic pain, and treatment related factors
Time frame: 12 months
Genetic markers and the development of persistent pain after breast cancer treatment
Time frame: 12 months postoperative
QST profile 1 week after surgery for breast cancer
Detailed QST profile 1 week after surgery for breast cancer. Patients will be assessed with sensory mapping, followed by assessment of mechanical and thermal thresholds.
Time frame: 1 week postoperative
Acute pain after surgery for breast cancer
Prevalence of acute pain 1 week after surgery for breast cancer.
Time frame: 1 week postoperative
Test-Retest of QST after breast cancer treatment
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A test-retest series of a subgroup of patients assessed with QST, to evaluate methodological reliability. Patients are scheduled to 2 QST assessments with a week between.
Time frame: 12 months postoperative