Preventing Myocardial Ischemia by Preconditioning in Elective Operation for Abdominal Aortic Aneurysm

Aarhus University Hospital200 enrolled

Overview

Primary To investigate whether peripheral predonditioning induced by brief, intermittent constriction of blood supply to an arm can reduce the incidence of perioperative myocardial ischemia in patients operated electively for infrarenal aortic aneurysm. Secondary To investigate the impact of peripheral preconditioning on perioperative inflammatory response. To investigate whether peripheral preconditoning can protect against perioperative myocardial infarction and reduced cardiac pump function.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

200

Conditions

Aortic Aneurysm

Interventions

preconditioningPROCEDURE

peripheral preconditioning induced by brief, intermittent constriction of blood supply to an arm

Normal surgery, with sham intervention without inflating arm cuffPROCEDURE

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * All patients older than 18 years, hospitalized for elective surgery of abdominal aortic aneurysm Exclusion Criteria: * Lack of informed consent. * Hemiparetic patient. * Pregnancy or nursing patient.

Locations (2)

Aalborg Hospital

Aalborg, Aalborg, Denmark

NOT_YET_RECRUITING

Aarhus University Hospital, Skejby

Aarhus, Aarhus N, Denmark

RECRUITING

Outcomes

Primary Outcomes

measurements of CKMB and Troponin T

Time frame: 30 days

Data from ClinicalTrials.gov

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