Repeating Patterns of Sleep Restriction and Recovery

Beth Israel Deaconess Medical Center17 enrolled

Overview

Goal of this study is to test the hypothesis that repeated exposure to cycles of insufficient sleep increases susceptibility to a variety of disease states by progressively compromising the integrity of stress response systems.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

Healthy

Interventions

Repeated sleep restriction and recoveryBEHAVIORAL

Repeated cycles of sleep restriction and sleep recovery

Control sleepBEHAVIORAL

Regular amounts of sleep across study protocol

Eligibility

Sex: ALLMin age: 18 YearsMax age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Body mass index (BMI) between 18.5 and 30 kg/m2 * For female participants: regular menstrual cycles * Daily sleep duration in the normal range * Blood chemistry in the normal range Exclusion Criteria: * Active infection/disease * History of psychiatric, neurological, pain-related, immune, or cardiovascular disease; significant allergy * Pregnant/nursing * Respiratory disturbance index of \>5 events/hour on polysomnographic sleep study, leg movements with arousal \>10/hour; sleep efficiency \<80% * Regular medication use other than oral contraceptives * Donation of blood or platelets 3 month prior to or in-between study arms

Locations (1)

Beth Israel Deaconess Medical Center

Boston, Massachusetts, United States

Outcomes

Primary Outcomes

stress-related markers

cortisol, ACTH, norepinephrine, IL-6, COX in blood/urine, among others

Time frame: Participants will be followed for the duration of hospital stay, an axpected average of 2 x 25 days.

Secondary Outcomes

subjective stress-related markers

Computerized rating scales for the assessment of physical and emotional well-being

Time frame: Participants will be followed for the duration of hospital stay, an axpected average of 2 x 25 days.

Data from ClinicalTrials.gov

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