Safety Study of HPP593 in Subjects During and After Limb Immobilization

Inclusion Criteria: * Non-smoking. * Subjects must be in good health, as determined by medical history, physical examination, vital signs, electrocardiogram (ECG), and clinical test results. * Not restricted to a wheel-chair or confined to a bed. * Weight ≥ 50.0 kg. * BMI between 18 and 27.5 kg/m2, inclusive, at the time of screening. Exclusion Criteria: * Any of the following abnormalities at Screening Visit and Baseline: * Fasting glucose \> 110 mg/dL (Screening visit only). * Serum creatinine \> 1.5 mg/dL. If serum creatinine is \>1.5 mg/dL and creatinine clearance is \>60 mL/min, the subject need not be excluded * Troponin I level above the upper limit of normal (ULN) * Liver function tests (LFTs) \> 1.5x ULN * Evidence of significant organ system dysfunction (e.g. diabetes, cardiovascular disease, cirrhosis, hypogonadism, hypo- or hyperthyroidism; hypertension) * Any fluctuations in weight (no more than ± 2% of body weight) by subject self report in the 3 months prior to the Screening Visit. * Has received HPP593 in a previous clinical trial. * Smoking within 6 month prior to Day -1. * Michigan Alcohol Screening Test score greater than 2.