Per-Oral Endoscopic Myotomy (P.O.E.M.) for Treatment of Primary Esophageal Motility Disorders

Chinese University of Hong Kong20 enrolled

Overview

Spastic esophageal motility disorders induced significant symptoms including dysphagia, retrosternal pain and regurgitation. Per oral endoscopic myotomy (P.O.E.M.) is a novel approach to perform myotomy through the esophagus with long submucosal tunnel. This study aimed to investigate the feasibility and safety of P.O.E.M. and translate the techniques from animal study to clinical practice in human.

Study Type

INTERVENTIONAL

Allocation

Masking

NONE

Enrollment

Conditions

Achalasia

Interventions

Per Oral Endoscopic MyotomyPROCEDURE

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * All patients with age ranged 18 to 80 who had primary esophageal motility disorders will be recruited. The primary motility disorders included: Achalasia, hypertensive LES, Nutcracker esophagus and Diffuse esophageal spasm. Exclusion Criteria: * Patients will be excluded from this study with the followings - 1. Pregnancy 2. Informed consent not available 3. Previous history of esophagectomy or mediastinal surgery 4. Previous history of endoscopic resection for early esophageal cancers, including endoscopic mucosal resection and endoscopic submucosal dissection 5. End-stage Achalasia with dilated esophagus more than 6cm on Barium swallow Investigations before and after POEM

Locations (1)

Department of Surgery, Chinese University of Hong Kong

Hong Kong, Hong Kong

RECRUITING

Outcomes

Primary Outcomes

Dysphagia score

Secondary Outcomes

Improvement in LES pressure

Eckhart score

Operative time

Length of myotomy

Time to resume diet

Morbidities

Central Contacts

Philip WY Chiu, MD

CONTACT

26322627 philipchiu@surgery.cuhk.edu.hk

Data from ClinicalTrials.gov

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