A Clinical Study of Trazodone Hydrochloride Prolonged-Release Tablets for Treatment of Depression

Inclusion Criteria: 1. Age between 18 and 65, males and females, outpatients or inpatients; 2. Single episode or recurrent depression according to DSM-IV (Version 4) criteria; 3. Scores \> 18 on 17-item HAM-D at screening and baseline visits with a decrease not exceeding 20% between the two visits; 4. Symptoms of depression for at least 1 month; 5. Patients or their dependents/guardians providing signed informed consent forms. Exclusion Criteria: 1. Serious suicide attempts (≥ 3 on item 3 'Suicide' of HAMD); 2. Depressive episode, with psychotic symptoms; 3. Refractory depression; 4. Depressive episode secondary to other mental or physical disorders; 5. Bipolar disorder; 6. Significant reduction in body weight and malnutrition induced by major depression; 7. Serious or unstable heart, hepatic, renal, endocrine and hematologic disease or malignant tumors;