Validation of Functional Imaging as Predictive Tool for Outcome of Mandibular Replacement Appliance Therapy in Obstructive Sleep Apnea Hypopnea Syndrome Patients

Inclusion Criteria: 1. Patients with documented OSAHS based on the following criteria: AHI \>= 5 Complaints of extreme daytime sleepiness with no other explanation and/or 2 or more of the following symptoms: * choking or gasping during sleep * recurrent awakenings from sleep * un-refreshing sleep * daytime fatigue * impaired concentration 2. Patients who received MRA as treatment for OSAHS 3. AHI \>= 5 on at least 1 of the screening nights (patient does not wear MRA device) 4. Male or female patients aged ≥ 18 years 5. Patients with a co-operative attitude 6. Written informed consent obtained Exclusion Criteria: 1. Pregnant or lactating females or females at risk of pregnancy 2. Patients with an uncontrolled disease or any condition that might, in the judgement of the investigator, place the patient at undue risk or potentially compromise the results or interpretation of the study. 3. Cancer or any other chronic disease with poor prognosis and/or affecting patient status 4. History of alcohol or drug abuse in the last 2 years 5. Patients unlikely to comply with the protocol or unable to understand the nature, scope and possible consequences of the study 6. Patients who participate in another clinical study whose investigational plan is judged to interfere or affect any of the measures of this study