A Randomized Clinical Trial of the Effect of Pimecrolimus Cream 1% Compared With Topical Corticosteroid in Treatment of Erosive Oral Lichen Planus

Mashhad University of Medical Sciences40 enrolled

Overview

The purpose of this study is to compare the effect of topical Pimecrolimus with adcortyl on erosive-atrophic 0ral lichen planus in a randomized clinical trial study.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Oral Lichen Planus

Interventions

Pimecrolimus ointmentDRUG

Case group used drugs 3 times a day for 2 months and then didn't eat or drink for 20 minutes after use

AdcortylDRUG

triamcinolone acetonide 0.1% in orabase

Eligibility

Sex: ALLMin age: 8 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Biopsy confirmed oral lichen planus in combination with a compatible clinical appearance was used for diagnosis. Exclusion Criteria: * Unable to undergo oral biopsy for diagnosis * Systemic diseases or malignancy * Pregnancy * Lesion/lesions with dysplasia/ history of allergic reaction to corticosteroids or immunomodulatory drugs. * Lesions adjacent to amalgam filling were also excluded from this study.

Locations (1)

Mashhad University of Medical Science

Mashhad, Khorasan Razavi, Iran

Outcomes

Primary Outcomes

signs of oral lichen planus

size and type of oral lichen planus has been recorded

Time frame: every 2 weeks

Secondary Outcomes

symptoms of oral lichen planus

pain of oral lesions has been recorded

Time frame: every 2 weeks

Data from ClinicalTrials.gov

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