This clinical trial is designed to compare the pharmacokinetic characteristics of combination and separate administration of Crestor(Rosuvastatin) and Glucodown(Metformin SR). Also investigate drug interaction between separate and combination administration. Total number of subjects is 36. 6 group(6 for 1 group), 3 period, consecutive 5 day administration, 10 days washout after 5th day of administration. All subjects take Crestor alone, Glucodown alone, Crestor+Glucodown combination during 3 each period.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Masking
NONE
Enrollment
36
For co-administration,Crestor 1 tablet and Glucodown 1 tablet a day for 5 day.(1 period) For separate administration, Crestor 1 tablet a day for 5 day and Glucodown 1 tablet a day for 5 day.
Severance Hospital, Yonsei University
Seoul, South Korea
AUCtau
Time frame: 72 hr
Css,max
Time frame: 72 hr
AUCss,last
Time frame: 72 hr
AUCss,inf
Time frame: 72 hr
Css,min
Time frame: 72 hr
Tss,max
Time frame: 72 hr
t1/2
Time frame: 72 hr
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