Safety, Tolerability and Efficacy of YH14618 in Patients With Degenerative Disc Disease

Inclusion Criteria: * Have signed a written informed consent voluntarily, prior to the any procedure * Degenerative disc disease patients of aged over 20 years * Have one or more of the symptomatic lumbar level(L1\~S1) as confirmed using radiology(X-ray, MRI and/or discogram/CT) * Have been diagnosed 2\~3 degree of MRI index by modified thompson classification * Oswestry diability index(ODI) of 30 or greater * Visual analog scale(VAS) of 4 or greater Exclusion Criteria: * Subjects unable to have radiological examination * Have history of neurological disease, herniated lumbar disc, compression fractures and lumbar spinal surgery * Sacroiliac joint dysfunction * Have been treated with any drugs for pain control within 7 days prior to the first administration * Hypersensitivity to drugs * Pregnant women, nursing mothers or subjects who do not agree to assigned contraception in the study * Participated in any other clinical trials within 30 days prior to the first administration