Home Non-invasive Ventilation for Chronic Obstructive Pulmonary Disease Patients

University Hospital, Rouen12 enrolled

Overview

Chronic Obstructive Pulmonary disease (COPD) patients with chronic hypercapnic respiratory failure are more likely to develop exacerbations. Non-invasive ventilation has been proposed to treat acute respiratory failure but little information is available about the benefits of home non-invasive ventilation in COPD patients with chronic hypercapnic respiratory failure surviving an acute hypercapnic respiratory failure. The purpose of this study is to determine whether home non-invasive ventilation can reduce recurrent acute hypercapnic respiratory failure in COPD patients who survived an episode of acute hypoxemic respiratory failure (AHRF) treated by Non-invasive ventilation (NIV).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Chronic Obstructive Pulmonary Disease Hypercapnic Respiratory Failure

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age \> 18 years old * COPD patients who survived after an episode of acute hypercapnic respiratory failure * Patients weaned from ventilation (non invasive ventilation or mechanical ventilation) for acute episode since at least seven days with stable arterial blood gas since at least two days: PaCO2 \> 55 mmHg and pH \> 7.35 Exclusion Criteria: * Age \> 85 years old * Non- COPD causes of respiratory failure * Obstructive sleep apnea excluded by polysomnography * Adverse psychosocial status * Serious co-morbidity

Outcomes

Primary Outcomes

Acute hypercapnic respiratory failure episode

Time frame: up to 102 weeks

Secondary Outcomes

Death

Time frame: 1 month and every 6 months during 2 years