Fiber Longer Term Study on Energy Intake

Wageningen University35 enrolled

Overview

Dietary fibre seems to have a relevant role in body weight management. In an acute study the investigators found that high viscous-high gelling pectin increased feelings of satiety. The objective of this study is to study the effects of 2 weeks of supplementation of high gelling-high viscous fibre or a high gelling-high viscous non-fibre control on energy intake. The investigators do this by measuring the difference in ad libitum energy intake after 15 days of pectin or 15 days of control supplements. The investigators will further measure differences in 24h feelings of satiety, fasting blood glucose and insulin, fermentation and composition of microbiota.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

QUADRUPLE

Enrollment

Conditions

Healthy

Interventions

LM pectin (10%)DIETARY_SUPPLEMENT

15 days 1 daily consumption of a drink with 10g pectin added

gelatinDIETARY_SUPPLEMENT

15 days 1 daily consumption of a drink with 10g gelatin added

Eligibility

Sex: ALLMin age: 18 YearsMax age: 30 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age: 18-30 year * BMI: 18.5-25 kg/m2 * Healthy: as judged by the participant * H2 producer Exclusion Criteria: * Weight loss or weight gain of more than 5 kg during the last 2 months * Using an energy restricted diet during the last 2 months * Lack of appetite for any reason * Restrained eater * Smoking * Heavy alcohol use: \>5 drinks/day * Reported stomach or bowel diseases or disorders (e.g. irritable bowel syndrome) * Reported diabetes * Reported thyroid disease or any other endocrine disorder * Using medication other than birth control, paracetamol, aspirin, hey fever and asthma * Antibiotic use \<2 months before the study * Reported intolerance, allergy, or not liking of the research foods * Vegetarian * Current dietary fibre supplementation * Fasting glucose levels \>5.8 mmol/l * Experienced any problems with drawing blood in the past * Thesis students or employees of the division of Human Nutrition * Volunteers who participated in the ProVe study

Locations (1)

Wageningen University

Wageningen, Netherlands

Outcomes

Primary Outcomes

Energy intake

after 14 days of both intervention and placebo supplements ad libitum energy intake is measured for 3 days in a row. The change in energy intake will be calculated.

Time frame: change from placebo after 2 weeks

Secondary Outcomes

satiety

at day 1 and after 15 days of both supplement and placebo intake satiety is measured hourly over 1 day at waking hours. The change in satiety will be calculated.

Time frame: change from placebo after 1 day and 15 days

fasting glucose

at day 0, 1 and day 15 of supplementation period fasting glucose is measured

Time frame: change from placebo after day 0, 1 and 15

fasting insulin

at day 0, 1 and day 15 of supplementation period fasting insulin is measured

Time frame: change from placebo after day 0, 1 and 15

fasting leptin

at day 0, 1 and day 15 of supplementation period fasting leptin is measured

Time frame: change from placebo after day 0, 1 and 15

hydrogen in breath

at day 2 and at day 15 hydrogen is measured hourly over 1 day at waking hours

Time frame: change from placebo after day 2 and 15

energy intake

before supplement intake and after 1 day of supplement 1-day ad libitum energy intake is measured. The change in energy intake will be calculated.

Time frame: change from placebo after day 0 and 1

Data from ClinicalTrials.gov

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