Timing of Surgical Intervention After Percutaneous Catheter Drainage in STEP UP Approach for Severe Acute Pancreatitis

Post Graduate Institute of Medical Education and Research, Chandigarh40 enrolled

Overview

1. To determine the appropriate timing of surgical intervention after Percutaneous Catheter Drainage (PCD) in infected pancreatic necrosis (IPN). 2. To see the change in morbidity and mortality after changing the interval of surgery after PCD

In present study we plan to determine the appropriate timing of surgical intervention after PCD in step up approach of Infected pancreatic necrosis (IPN). The investigators also intend to evaluate the role of PCD in obviating the surgical intervention in the management of IPN and evaluate the risks \& benefits of extended treatment policy of PCD in step up approach of IPN in comparison to early surgery after PCD.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Acute Pancreatitis

Interventions

surgical intervention after percutaneous catheter drainagePROCEDURE

Patients who are not improving by day 10 after PCD insertion will be included in the present study and are randomized to group A (early surgery i.e. between 10-15days after PCD insertion ) or group B (Extended treatment with PCD with saline irrigation for more than 15days after PCD insertion)

Eligibility

Sex: ALLMin age: 14 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: * All patients with diagnosis of IPN (UK GUIDELINES) managed with percutaneous catheter drainage (PCD) for 10 to 15 days and not showing significant improvement on PCD will be included Exclusion Criteria: 1. Patient showing significant improvement on PCD within 10 days of its insertion.(Significant improvement on PCD is defined as resolution of fever, acceptance of enteral nutrition, decrease in total leukocyte count, reversal of organ system failure) 2. Sterile pancreatic necrosis 3. An acute intra abdominal event ( perforation of hollow viscus, bleeding, or the abdominal compartment syndrome) during or within 10 days after PCD insertion 4. Previous drainage or surgical necrosectomy for infected pancreatic necrosis (ERCP with or without papillotomy is allowed.) 5. Previous exploratory laparotomy for acute abdomen and diagnosis of pancreatitis during laparotomy

Locations (2)

PGIMER

Chandigarh, Chandigarh, India

Postgraduate Institute of Medical Education and Research

Chandigarh, India