Neuroprotection Impact of Cyclosporin A in Cerebral Infarction

Inclusion Criteria: * Patients age ≥ 18 years and \<85 years * Male or female, * Patients with cerebral infarction of less than 4:30H, * NIHSS score between 6 and 18 * Identification of a carotid artery occlusion in the territory in MRI * Consent of participation signed by the patient or, if it is unable to give the family or someone you trust if it is present. * Patient beneficiary of a social security system. Exclusion Criteria: * Known hypersensitivity to cyclosporin A or castor oil, polyoxyethylene * Patient in St. John's wort, stiripentol, bosentan or rosuvastatin * History of immunosuppression recent (\<6 months): cancer, lymphoma, positive serology for HIV, hepatitis, ... * Known hepatic (prothrombin time \<50%) * Patients treated with sulfonylureas or nicorandil * Patients treated with dopamine, adrenaline, noradrenaline or isoprenalin * Uncontrolled hypertension defined as systolic blood pressure greater than 185mm Hg and a diastolic pressure above 110 mmHg, * Cardiogenic shock defined by systolic blood pressure below 80 mm Hg * Contraindication to thrombolysis: History of AIC in the three months history of intracranial hemorrhage, neoplasm, subarachnoid hemorrhage, arteriovenous malformation * Presumption of septic embolism or aortic dissection or pericardial effusion. * Recent biopsy or surgery within 3 months * Head injury less than 3 months * Known bleeding diathesis, taking anticoagulants with INR\> 1.2 * Hypoglycemia (blood glucose below 0.5 mmol / l) * Known renal, creatinine greater than 130 Mu / L * Recent Lumbar puncture \<7days * Conditions prior psychiatric or neurological deficit does not allow objective analysis of disability * History of ischemic stroke or hemorrhagic * History of epilepsy and taking antiepileptic * Exclusion criteria Imaging * Structured hypodensity scanner compatible with recent ischemic stroke * Hematoma * Other lesions (tumor or inflammatory cerebral venous thrombosis) * The scanner Contraindications: allergy to iodine or major renal creatinine\> 130μl or MRI referred to above * Women of childbearing age, pregnant or not recognized effective contraception * Patients in the measure of legal protection.