Studying Genes in Samples From Younger Patients With Adrenocortical Tumor

Children's Oncology Group10 enrolled

Overview

RATIONALE: Studying samples of blood and tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research trial studies genes in samples from younger patients with adrenocortical tumor.

OBJECTIVES: * To perform whole-genome sequencing, deep sequencing, micro RNA analysis, methylation status, copy number variation analysis, and single-nucleotide polymorphisms (SNPs) analysis in pediatric adrenocortical tumors and compare those results to those of the same patient's normal cells. OUTLINE: Archived tumor and blood samples are analyzed for whole-genome sequencing, deep sequencing, micro RNA , methylation status, copy variation, and single-nucleotide polymorphisms. Results are then compared with patients' normal cells.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Adrenocortical Carcinoma

Interventions

DNA methylation analysisGENETIC

RNA analysisGENETIC

gene expression analysisGENETIC

nucleic acid sequencingGENETIC

Eligibility

Sex: ALLMax age: 21 Years

Medical Language ↔ Plain English

DISEASE CHARACTERISTICS: * Banked tumor and blood samples obtained from patients enrolled on COG-ARAR0332 in North America and Brazil PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * Not specified

Outcomes

Primary Outcomes

Identification of genetic factors affecting adrenocortical tumors

Comprehensive catalog of altered genes in adrenocortical samples

Data from ClinicalTrials.gov

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