Safety and Metabolic Study of Highly Active Antiretroviral Therapy (HAART) in Malnourished Children With HIV

Washington University School of Medicine42 enrolled

Overview

It is unclear whether children with HIV and severe acute malnutrition can be started on highly active antiretroviral therapy (HAART) safely while they are still malnourished and the manner in which this therapy should start. This study will examine the safety, efficacy, and metabolism of children started on HAART while still severely malnourished.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Kwashiorkor Marasmus Severe Acute Malnutrition HIV

Interventions

zidovudine, lamivudine, nevirapineDRUG

Eligibility

Sex: ALLMin age: 6 MonthsMax age: 59 Months

Medical Language ↔ Plain English

Inclusion Criteria: * HIV-infected about to start on HAART for the first time * 6-59 months old Exclusion Criteria: * also being treated for TB * other chronic illness (e.g., congenital heart disease, cerebral palsy)

Locations (1)

Queen Elizabeth Central Hospital

Blantyre, Malawi

Outcomes

Primary Outcomes

Pharmacokinetics

PK of ART in malnourished children

Time frame: 6 weeks

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.