Non-invasive Measurements of Elastance and Resistance

University of Turin, Italy15 enrolled

Overview

The study aims to assess the agreement between respiratory mechanics parameters measured noninvasively by means of brief airways occlusions at the beginning of inspiration and the reference parameters obtained with standard techniques of esophageal and gastric pressure under static and dynamic conditions in a mixed population of ICU patients mechanically ventilated in pressure support ventilation mode.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Respiratory Insufficiency

Interventions

Invasive methodOTHER

Esophageal and gastric catheters to measure respiratory mechanics (static and dynamic)

Non invasive methodOTHER

Non\_invasive method: airway pressure measured during a 150-200 ms at the beginning of inspiration

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * intact respiratory drive; * PaO2/FiO2 ratio \> 150 with a positive end-expiratory pressure (PEEP) ≤ 8 cmH2O; * pH between 7.35 and 7.45; * patient alert, conscious, and cooperative with a Glasgow Coma Scale ≥ 10. Exclusion Criteria: * infection, sepsis or septic shock; (with fever no) * hemodynamic instability; * respiratory centres depression; * esophageal deformity, or gastric/esophageal illnesses; * previous recent gastric/esophageal surgery.

Outcomes

Primary Outcomes

Non-invasive respiratory mechanics measurement

use of 150-200 ms airway occlusions at the beginning of inspiration to measure non-invasive respiratory mechanics

Time frame: 2 hours

Central Contacts

Vito Marco VM Ranieri, MD

CONTACT

+39 0116334001 marco.ranieri@unito.it

Gabriela G Ferreyra, MSC

CONTACT

+39 0116334001 gabriela.ferreyra@unito.it

Data from ClinicalTrials.gov

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