Efficacy and Tolerability of Propiverine Hydrochloride in Patients With Neurogenic Detrusor Overactivity

Inclusion Criteria: * Male or female Caucasian patients aged ≥18 and ≤70 years * Voluntarily signed informed consent * Neurogenic detrusor overactivity with occurrence of reflex detrusor contractions * Reflex volume of ≤250 mL * Intact reflex arcs in the area of segments S2-S4 Exclusion Criteria: * Patients suffering from multiple sclerosis under unstable conditions * Augmented reflex bladder * Patients with increased residual urine (≥20 % of the maximum bladder capacity), in whom catheterization is not possible * Acute urinary tract infection * Electrostimulation therapy (within 4 weeks propir to Visit 1) * Anomalies of the lower genitourinary tract (e.g. ectopic ureters, fistulas, urethral stenosis) * Radiation bladder, interstitial cystitis, bladder calculi, bladder carcinoma * Surgery of the lower genitourinary tract within the last 6 months (e.g. prostatectomy, hysterectomy, tumor surgery) * Pre-existing medical contraindications for anticholinergics * Cardiac insufficiency (NYHA stage III/ IV) * Therapy with botulinum toxin within the last 12 months * Evidence of severe renal, hepatic or metabolic disorders * History of drug or alcohol abuse * Concomitant medication known to have a potential to interfere with the trial medication * Known hypersensitivity to Propiverine hydrochloride or excipients contained in the trial medication, respectively * Pregnant or breast-feeding women, or women of childbearing potential without using any reliable contraceptive method * Patients with impaired co-operation or who are unable to understand the nature, scope and possible consequences of the study