Observe the effect of terlipressin on renal function in patients with SHR type I adjusting the dose based on hemodynamic response.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
40
Terlipressin dose: 2mg/24h, it will be modified depending on: Arterial pressure increase \< 10 mmHg and the creatinine values decrease \<25%, it will be increased every 8 hours until reaching an increase of at least 10mmHg arterial pressure or a creatinine decrease of the 25%. Albumin: Initial dose (first day) of 1g/Kg (up to a maximum of 100g) and the following days from 20 to 40 g/day.
Hospital Clinic i Provincial de Barcelona
Barcelona, Barcelona, Spain
Hospital del Mar
Barcelona, Barcelona, Spain
Hospital Vall d´Hebron
Barcelona, Barcelona, Spain
Hospital de la Santa Creu i Sant Pau
Barcelona, Barcelona, Spain
Changes in arterial pressure and creatinine
Time frame: 4 months
Changes in plasmatic renin activity and aldosterone and noradrenaline concentration.
Time frame: 4 months
Treatment-related adverse events
Time frame: 4 months
Hepatorenal Syndrome reversion due to hemodynamic changes.
Time frame: 4 months
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Corporació Sanitària Parc Taulí
Sabadell, Barcelona, Spain
Hospital Moisés Broggi
Sant Joan Despí, Barcelona, Spain