The investigators hypothesize that differential dynamics in fat depots in response to two opposing dietary strategies mediate the beneficial metabolic effects during weight loss and regain phases.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
224
Weight-loss diet strategy with a free gym membership; monthly 60-minute educational workshops; 3 sessions of workout per week of mostly aerobic training
Weight-loss diet strategy without exercise
nuclear research center Negev
Dimona, Israel
body fat composition
changes in body fat (MRI)
Time frame: 0, 6,18 months
obesity
changes in weight
Time frame: 0, 6, 18 months
abdominal obesity
changes in waist circumference
Time frame: 0, 6, 18 months
Lipid profile
Changes in lipid biomarkers: total cholesterol (mg/dL), triglycerides (mg/dL), HDLc (mg/dL), LDLc (mg/dL) (blood draw)
Time frame: 0, 6, 18 months
Glycemic control
Changes in fasting glucose (mg/dL) (blood draw)
Time frame: 0, 6, 18 months
Glycemic control
Changes in insulin (μIU/mL) (blood draw)
Time frame: 0, 6, 18 months
Inflammatory state
Changes hsCRP (mg/L) (blood draw)
Time frame: 0, 6, 18 months
Metabolomic
Changes in sub-lipids (blood draw)
Time frame: 0, 6, 18 months
Metabolomic
Changes in sub-proteins ( blood draw)
Time frame: 0, 6, 18 months
Liver function (blood biomarkers)
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Changes in ALT (U/l), AST (U/l), ALKP (U/I), GGT (U/l) (blood draw)
Time frame: 0, 6, 18 months
Genetic signature
SNPs (variants) associated with fat distribution and visceral fat (blood draw)
Time frame: baseline
Epigenetics
changes in genes' methylation (blood draw)
Time frame: 0, 6, 18 months
Epigenetics
changes in mRNAs (blood draw)
Time frame: 0, 6, 18 months