The main purpose of this research study is to evaluate the effectiveness of a minimally invasive surgical approach to removing parathyroid gland(s). The researchers are also interested in analyzing abnormal parathyroid tissue for changes in genes and proteins that may contribute to overactive parathyroid gland(s).
The specific aims of this study are to determine the safety and efficacy of minimally invasive radioguided parathyroidectomy, to determine the positive and negative predictive value of sestamibi scanning to detect parathyroid adenomas, and to differentiate adenomas from parathyroid hyperplasia. In addition, this study aims to determine the value of intraoperative parathyroid hormone assay to verify biochemical cure of primary hyperparathyroidism, to determine whether minimally invasive radioguided parathyroidectomy is cos-effective, and to collect abnormal parathyroid tissue at the time of surgery for tissue analysis.
Study Type
OBSERVATIONAL
Enrollment
856
After the patient is prepared for surgery and under local anesthesia, the initial incision by the surgeon will be 2-3 cm. The surgeon will dissect in the designated quadrant until the parathyroid gland is identified.
University of Louisville
Louisville, Kentucky, United States
The positive and negative predictive value of sestamibi scanning to detect parathyroid adenomas.
Time frame: 2-3days
The value of intraoperative parathyroid hormone assay to verify biochemical cure or primary hyperparathyroidism
Time frame: 2-3 days
Collection of abnormal parathyroid tissue at the time of surgery for tissue analysis
Time frame: day of surgery (1 day)
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